CYP3A5 Gene Variation Influences Cyclosporine A Metabolite Formation and Renal Cyclosporine Disposition
نویسندگان
چکیده
منابع مشابه
Diurnal variation in cyclosporine kinetics.
Cyclosporine (Cy A) is now considered a primary immunosuppressant used to prevent organ rejection in liver, kidney, and heart transplant patients (1-3). It has been recommended that the blood level of Cy A be monitored in these patients to minimize the possibility of rejection due to low CyA blood concentrations or potential toxicity due to high CyA concentrations (4,5). This is based on the ob...
متن کاملIMMUNOSUPPRESSION BEFORE CYCLOSPORINE Renal Transplantation
The concept of liver transplantation is a relatively recent one. The first descriptions of liver replacement in experimental animals were published less than 25 years ago,I,2 and the first attempt at clinical liver transplantation was not made until March I, 1963.3 The pace of clinical trials remained limited until 1980, the year when the new immunosuppressive agent cyclosporine was introduced....
متن کاملAntioxidant properties of repaglinide and its protections against cyclosporine A-induced renal tubular injury
Objective(s): Repaglinide (RG) is an antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus. It has a good safety and efficacy profile in diabetic patients with complications in renal impairment and is an appropriate treatment choice, even for individuals with more severe degrees of renal malfunctions. The aim of the present study was to examine the protective...
متن کاملHepatic disposition of cyclosporine A in isolated perfused rat livers.
PURPOSE To develop an isolated perfused rat liver model to study the hepatic disposition of cyclosporine A (CyA) in both sexes. METHODS Livers were isolated from male (n = 6) and female (n = 7) rats and perfused with a physiological buffer in a single-pass manner. A bolus 1-mg dose of CyA was injected into the inlet catheter and periodical samples (0-15 min) were collected from the outlet per...
متن کاملCyclosporine-A induced neurotoxicity after renal transplantation.
Cyclosporine-A is a highly potent immunosuppressive agent for solid organ transplantation, but has many side effects including nephrotoxicity, hypertension, gum hyperplasia, hepatotoxicity, and neurotoxicity. Neurotoxicity is a less known toxic effect. The pathogenesis of this effect is unclear. However, it has been postulated that hypomagnesemia, hypocholesterolemia, corticosteroids, and/or ne...
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ژورنال
عنوان ژورنال: Transplantation
سال: 2013
ISSN: 0041-1337
DOI: 10.1097/tp.0b013e31827e6ad9